Mitochondria

This BBC Radio 4 podcast episode of "In Our Time" features a discussion about mitochondria, the power packs of cells, with experts Florence Camus, Mike Murphy, and Nick Lane. The conversation covers the structure, function, and origin of mitochondria, including their role in energy production (ATP), their unique DNA, and the endosymbiotic theory explaining their incorporation into complex cells. The panel explores the historical scientific discoveries related to mitochondria, their involvement in diseases like cancer, their maternal inheritance, and their potential role in aging. They also touch on new techniques like mitochondrial replacement therapy and the possibility of manipulating mitochondria to treat diseases, as well as future research directions.

Outlines

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In Our Time

Introduction to Climate Change Lawsuits and Mitochondria

ATP Molecules and the Astonishing Scale of Mitochondrial Energy Production

Mitochondrial DNA and the Endosymbiotic Theory

The Discovery of Mitochondria and the Chemiosmotic Coupling Hypothesis

Endosymbiosis, Mitochondrial Roles Beyond Energy Production, and Maternal Inheritance

Degeneration, Adaptation, and Viral Manipulation of Mitochondria

Mitochondrial Function in Disease, Three-Parent Children, and Aging

Future Research Directions: Mitochondrial Communication, Medicine, and Transplants

Mitochondrial Replacement Therapy and Concluding Remarks

Mitochondria

In Our Time

00:05Introduction to Climate Change Lawsuits and Mitochondria

Introduction to Climate Change Lawsuits and Mitochondria

06:13ATP Molecules and the Astonishing Scale of Mitochondrial Energy Production

ATP Molecules and the Astonishing Scale of Mitochondrial Energy Production

12:03Mitochondrial DNA and the Endosymbiotic Theory

Mitochondrial DNA and the Endosymbiotic Theory

17:12The Discovery of Mitochondria and the Chemiosmotic Coupling Hypothesis

The Discovery of Mitochondria and the Chemiosmotic Coupling Hypothesis

23:39Endosymbiosis, Mitochondrial Roles Beyond Energy Production, and Maternal Inheritance

Endosymbiosis, Mitochondrial Roles Beyond Energy Production, and Maternal Inheritance

29:56Degeneration, Adaptation, and Viral Manipulation of Mitochondria

Degeneration, Adaptation, and Viral Manipulation of Mitochondria

37:05Mitochondrial Function in Disease, Three-Parent Children, and Aging

Mitochondrial Function in Disease, Three-Parent Children, and Aging

44:31Future Research Directions: Mitochondrial Communication, Medicine, and Transplants

Future Research Directions: Mitochondrial Communication, Medicine, and Transplants

52:50Mitochondrial Replacement Therapy and Concluding Remarks

Mitochondrial Replacement Therapy and Concluding Remarks