This podcast episode explores the cultural shift towards AI in scientific research and its potential to uncover fundamentally new science. It highlights the impact of AlphaFold 2 in predicting protein structures and the use of deep learning in pushing the boundaries of biology and other scientific fields. The episode discusses the journey of developing AlphaFold 2 and its real-world applications, as well as the renaissance in structural biology driven by AI. It also touches upon the importance of open source in maximizing the societal impact of AI models. The speakers emphasize the significance of AI in advancing scientific research and the potential for AI to revolutionize healthcare and life sciences.