This episode explores the intersection of behaviorism and motivational interviewing (MI), featuring a conversation with clinical psychologist Dr. James Anderson. Against the backdrop of Dr. Anderson's journey from studying animal behavior to leading a psychiatry department, the discussion delves into the principles of behaviorism, particularly radical behaviorism, which emphasizes understanding behavior as a product of an individual's entire life experience. More significantly, the conversation highlights how this perspective fosters compassion and acceptance in therapeutic settings. For instance, Dr. Anderson illustrates how understanding antecedents, behaviors, and consequences can illuminate seemingly inexplicable actions, such as substance abuse or remaining in abusive relationships. As the discussion pivoted to MI, Dr. Anderson explains how MI's techniques, such as using open-ended questions and reflections, align with behavioral principles by selectively reinforcing "change talk" and de-emphasizing "sustain talk." In contrast to the sometimes cold perception of behaviorism, Dr. Anderson emphasizes that this approach cultivates empathy and helps clients develop a narrative that promotes self-compassion and hope for change. This means for practitioners that integrating a behavioral lens into MI can lead to more effective interventions by fostering understanding, acceptance, and a collaborative approach to behavior change. The episode concludes with Dr. Anderson discussing his work on psychedelic-assisted therapy for PTSD and opioid use disorder, reflecting the ongoing evolution of therapeutic approaches informed by behavioral science.