This podcast episode provides a science-based guide to supplementation, emphasizing a rational approach. The speaker structures the discussion around foundational supplements (vitamins, minerals, etc.), followed by single-ingredient supplements for sleep, hormone support, and cognitive enhancement. He stresses the importance of individual experimentation with single-ingredient supplements to determine optimal dosages and combinations, advocating for a systematic approach rather than a "shotgun" method. The speaker also highlights the crucial role of behavioral tools (sleep, exercise, light exposure) and nutrition as foundational elements before considering supplementation. A key takeaway is the recommendation to prioritize foundational nutrition before using supplements for specific outcomes, and to use single-ingredient formulations to better understand individual responses.