(0:00) Jason's new brand deal

(1:18) Bestie updates

(9:12) "Ligma/Johnson" blunder outside of Twitter HQ

(15:38) Surge of tech layoffs at Twitter, Stripe, Lyft, Opendoor, Chime and others; preparing for a longer downturn than originally anticipated

(35:28) Macro trends, big tech freezes hiring, how founders can think about the last 3 years and the next 3 years

(54:04) Midterm election preview, understanding the shift toward populism

(1:17:32) Science corner: Understanding Meta's AlphaFold competitor

Follow the besties:

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Intro Music Credit:

Intro Video Credit:

https://twitter.com/TheZachEffect

Referenced in the show:

https://twitter.com/dee_bosa/status/1587158734689767425

https://www.youtube.com/watch?v=vBkzm4a7iY4

https://www.cnn.com/2022/11/02/politics/cnn-poll-democrats-midterm-elections/index.html

https://www.axios.com/2022/11/04/trump-presidential-run-2024-announcement

https://about.fb.com/news/2022/11/ai-protein-research-could-drive-progress-in-medicine-clean-energy

E103: Tech layoffs surge, big tech freezes hiring, optimizing for profits, election preview & more

All-In with Chamath, Jason, Sacks & Friedberg