This interview podcast features Andrew Huberman, a neurobiology and ophthalmology professor, interviewing Dr. Jamil Zaki, a psychology professor specializing in social neuroscience. The discussion centers on cynicism, its impact on well-being and relationships, and how to cultivate "hopeful skepticism" as an alternative. Huberman and Zaki explore the developmental roots of cynicism, contrasting it with skepticism, and discuss how cultural factors and social environments influence its prevalence. Specific examples, such as the "trust game" and studies on workplace dynamics, illustrate the negative correlation between cynicism and various life outcomes, including happiness, health, and creativity. Listeners gain practical tools, including mindset shifts and behavioral strategies like "social savoring," to mitigate cynicism and foster more positive social interactions.