In this episode of the Scientific American podcast, we celebrate the 50th anniversary of the Arecibo message, which marked humanity's first conscious effort to reach out to extraterrestrial intelligence. Host Nadia Drake, daughter of the message's designer, shares insights into its creation and content, which include pictorial representations of human biology, our place in the solar system, and fundamental scientific principles encoded in binary. The discussion also highlights how the search for extraterrestrial intelligence (SETI) has evolved from focusing solely on radio waves to seeking broader technological signatures, reflecting a more serious scientific approach. The podcast wraps up by contemplating why the Arecibo message continues to captivate us, linking it to our deep-seated desire for connection and the wonder of our existence.