Many Amazon sellers are leaving the platform due to the growing challenges of the business, stricter regulations around invoicing and account setup, limited starting capital, and an increase in account deactivations. The speaker suggests that the future of Amazon wholesale lies in partnering with lesser-known brands directly from manufacturers or authorized distributors, targeting specific niches to reduce competition and the risk of account bans. The podcast also points out several common pitfalls that can lead to account suspensions, such as dropshipping from retail stores, selling counterfeit items, misrepresenting used products as new, manipulating reviews, and listing identical products across multiple accounts.