In this podcast, Dr. Mark Hyman interviews Dr. Eric Verdin, the CEO of the Buck Institute for Research on Aging. They delve into the science of aging and longevity, highlighting a shift in perspective: aging is no longer seen as an unavoidable decline but as a set of biological processes that we can potentially manage. The conversation touches on how to measure biological age using various "clocks," the critical role of mitochondrial function and NAD+, and the significance of nutrient-sensing pathways. They also discuss promising interventions like fasting, exercise, and certain supplements, while noting the importance of bioavailability and the need for further research. Throughout the discussion, they emphasize the interconnected nature of aging processes and the exciting potential of advancements in systems biology and AI to tailor longevity strategies for individuals.