This interview podcast features Lex Fridman interviewing Ilya Sutskever, OpenAI's co-founder and chief scientist, about deep learning and artificial intelligence. The conversation begins with a discussion of Sutskever's early intuitions about neural networks, drawing parallels to the human brain, and then progresses to explore key differences between biological and artificial neural networks. They delve into the role of cost functions in deep learning, the significance of the ImageNet moment, and the unifying principles across various AI domains like vision, language, and reinforcement learning. Sutskever expresses his belief in the potential of deep learning to achieve AGI, emphasizing the importance of self-play and the need for responsible model release strategies, as exemplified by OpenAI's staged release of GPT-2. The discussion concludes with reflections on the meaning of life and the importance of aligning AI values with human values.