This Invest Like the Best podcast episode features an interview with Tal Zaks, a physician scientist and biotech investor. The conversation begins with Zaks summarizing his career journey, transitioning from medical research and drug development (including his role at Moderna during COVID-19 vaccine development) to venture capital. The discussion then explores the current state and future potential of the therapeutics industry, focusing on the challenges of translating scientific breakthroughs into viable medicines and achieving financial returns. Zaks highlights the importance of aligning scientific innovation with investment strategies, emphasizing the need for a return on investment while acknowledging the long-term societal benefits of pharmaceutical advancements. Listeners gain insights into the investment process in the biotech sector, including the key variables considered (team, capital requirements, value inflection points, and probability of success), and learn about the complexities and uncertainties inherent in predicting the success of new therapeutics.