This monologue podcast features Morgan Stanley's Global Head of Fixed Income and Public Policy Research, Michael Zezas, discussing four key investment megatrends for 2025. The podcast begins by introducing the four megatrends: the rewiring of the global economy, longevity, the future of energy, and artificial intelligence. Zezas then elaborates on each trend, highlighting specific investment implications, such as the impact of AI on healthcare innovation and the increasing focus on energy security. For example, he notes that while 2024 saw a focus on AI infrastructure, 2025 will likely see a shift toward downstream AI applications driving efficiency and market share. The podcast concludes by emphasizing the interconnectedness of these trends and suggesting that understanding these dynamics is crucial for long-term investment strategies.