This NPR Up First news podcast covers three main stories. First, it reports on high-stakes US-Russia talks in Saudi Arabia aimed at ending the war in Ukraine, noting Ukraine's exclusion and potential deal outlines involving territorial concessions. Second, it details the Trump administration's significant job cuts in federal health agencies, impacting hundreds of employees, many with recent stellar performance reviews. Finally, it discusses the escalating political crisis in New York City, focusing on the resignation of four top aides to Mayor Eric Adams and Governor Hochul's consideration of removing him from office. The podcast concludes with a brief mention of other NPR podcasts.