This podcast discusses "American Dynamism," a thesis and subsequently a $600 million fund focused on startups building for the national interest. The hosts and guests trace the thesis's evolution from a controversial concept to a widely adopted framework, highlighting the shift in Silicon Valley's attitude towards supporting national interests. They analyze the reasons behind the initial controversy, focusing on the shift from a globally focused tech industry to one embracing national priorities. The discussion also covers the American Dynamism 50 list, which this year focuses on companies contributing to the Indo-Pacific region, emphasizing the importance of bolstering American capabilities in this area. Specific examples include companies developing attritable defense systems and addressing supply chain vulnerabilities.