This episode explores the development and applications of AG2 (formerly AutoGen), an open-source agent OS for building multi-agent systems. Against the backdrop of advancements in large language models (LLMs) like GPT, the founder, Chi Wang, discusses the challenges of efficiently leveraging these models for real-world applications. More significantly, the conversation delves into the concept of an "agent OS," outlining its key components: agent definition (supporting models, tools, and human input), agent interaction orchestration, and a layered approach to development and deployment. For instance, the discussion highlights AG2's unique capabilities, such as supporting diverse interaction patterns (sequential, group, nested chats, and Swarm) and features like teachability and automated task decomposition through a "captain agent." As the discussion pivoted to practical applications, several community-built examples were showcased, including chip design optimization at NVIDIA and bug fixing in software engineering, demonstrating AG2's versatility across various domains. In contrast to other frameworks, AG2's focus on advanced multi-agent capabilities and its early development provide a rich feature set. What this means for the future of AI development is a shift towards more intuitive and efficient workflows, empowering developers to build complex systems quickly and fostering collaboration between humans and AI agents.