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This episode explores the crucial role of nitric oxide in human health and longevity, featuring an interview with Dr. Nathan Bryan, a biochemist specializing in the subject. Against the backdrop of Dr. Bryan's personal experience in healing his father's non-healing wounds using nitric oxide, the discussion delves into the molecule's function in regulating blood flow and oxygen delivery. More significantly, the conversation highlights the link between nitric oxide deficiency and various age-related chronic diseases, including erectile dysfunction, high blood pressure, metabolic disorders, and Alzheimer's. For instance, Dr. Bryan emphasizes the importance of maintaining a healthy oral microbiome for optimal nitric oxide production, cautioning against the use of fluoride toothpaste and mouthwash. The interview also touches upon the role of diet, exercise, sunlight exposure, and even humming in influencing nitric oxide levels. Ultimately, the episode underscores the potential of nitric oxide-based therapies in revolutionizing healthcare and improving longevity, while also emphasizing the need for a holistic approach to health that considers lifestyle choices alongside medical interventions.