Your brain has a gear you’ve never touched. Psychedelics can shift you into it.

In this episode of The Human Upgrade, Dave Asprey uncovers how high-performance psychedelic mushrooms help you access flow states, rewire your brain, and enhance clarity, energy, and emotional resilience. This is next-level biohacking rooted in real science.

You will learn how to use psychedelics with intention. When to microdose. When to go deep. How to stack them with nootropics for even stronger results. Dave breaks down the latest research on psilocybin, brain plasticity, trauma release, and how to turn ancient compounds into modern performance tools.

What You Will Learn in This Episode:

• How psychedelic shrooms unlock flow, focus, and creative power

• Why psilocybin boosts neuroplasticity, mood, and emotional healing

• Microdosing vs. full-dose: what works, when, and how

• How to stack psychedelics with nootropics and other biohacks

• The newest research on brain optimization and long-term benefits

• How to use psychedelics safely, strategically, and for real results

• Why shrooms may be the strongest mental upgrade in your toolkit

Thank you to our sponsors!

-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.

-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.

Resources:

• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/

• Matt’s Website – https://mattzemon.com/

• Matt's Instagram - https://www.instagram.com/matt.zemon/

• 2025 Biohacking Conference: https://biohackingconference.com/2025

• Danger Coffee: https://dangercoffee.com

• Dave Asprey’s Website: https://daveasprey.com

• Dave Asprey’s Linktree: https://linktr.ee/daveasprey

• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com

• Own an Upgrade Labs: https://ownanupgradelabs.com

• Upgrade Labs: https://upgradelabs.com

• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com

Timestamps:

• 00:00 – Trailer

• 01:00 – Intro

• 06:01 – Personal Psychedelic Journeys

• 07:39 – Psychedelics and Self-Discovery

• 11:59 – Safe Use and Smart Navigation

• 29:09 – Psychedelics and Society

• 36:40 – Building Trust in the Process

• 37:14 – Facing Inner Fear

• 37:38 – Choice and Healing

• 37:51 – Diet and Conscious Decisions

• 38:55 – Judgment and Relationships

• 39:29 – Spirituality and Psychedelics

• 40:07 – The Entheogenic Reformation

• 41:29 – Past Lives and Expanded States

• 43:44 – Where Science Meets Spirituality

• 49:59 – Gratitude and Compassion in Healing

• 01:01:47 – The Power of Apologies

• 01:04:56 – Psychedelics in Therapy

• 01:08:57 – Final Thoughts on Psychedelics and Culture

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The New Science Behind Psychedelics, Exotic Shrooms, & Daily Flow-States | Matt Zemon : 1280

The Human Upgrade: Biohacking for Longevity & Performance