This episode explores the concept of failure, particularly within the healthcare system, and how it can be a catalyst for learning and improvement. The episode begins with the tragic story of Carol Hemmelgarn, whose daughter died due to medical errors, highlighting the need for transparency and systemic change in healthcare. Against the backdrop of medical errors, the case of nurse Redonda Vaught is examined, revealing the complexities of assigning blame in a system prone to failure. Organizational psychologist Amy Edmondson introduces a spectrum of failure, ranging from blameworthy acts like sabotage to praiseworthy experimentation, advocating for a shift from blame to systemic analysis. More significantly, the discussion pivots to real-world examples, such as the failed IT project within the UK's National Health Service, illustrating how a top-down approach and lack of experimentation can lead to costly failures. In contrast, scientist Bob Langer shares his experiences with repeated failures in research, emphasizing the importance of perseverance, learning from mistakes, and the potential for significant impact when success is achieved, reflecting emerging industry patterns where failure is accepted as a necessary part of innovation.