This Huberman Lab podcast episode focuses on nicotine's effects on the brain and body, distinguishing nicotine itself from its various delivery methods (smoking, vaping, etc.). The episode details nicotine's impact on dopamine, acetylcholine, and norepinephrine levels, explaining its effects on mood, focus, and metabolism. Specific examples include nicotine's appetite-suppressing mechanism via POMC neurons and the short-lived (30-45 minutes) cognitive enhancement it provides. The podcast concludes by discussing the dangers of smoking and vaping, highlighting the high relapse rates for quitting and suggesting methods like hypnosis (via the Reverie app) and bupropion (Wellbutrin) to aid cessation. Listeners gain a deeper understanding of nicotine's neurochemical effects and strategies for quitting nicotine addiction.
