06 Oct 2025
1h 26m

Lactate: The Key to Metabolic Health, Mitochondria, and Longevity | Dr Iñigo San Millán

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The Proof with Simon Hill

In this interview, Simon Hill and Dr. Inigo San Milan discuss lactate, challenging the outdated idea of it being a metabolic waste product. They explore lactate's role as a signaling molecule and fuel source, highlighting its importance in mitochondrial health and metabolic flexibility. The conversation covers how lactate contributes to glucose intolerance and type 2 diabetes, emphasizing the benefits of Zone 2 training for improving lactate clearance and enhancing endurance performance. They also touch on the limitations of VO2 max as a marker of mitochondrial health and the potential drawbacks of low-carb diets, advocating for a balanced approach to exercise and nutrition for optimal metabolic health and disease prevention.

Outlines

Part 1: Lactate Fundamentals

Part 2: Lifestyle, Mitochondria, and Metabolism

Part 3: Exercise Intensity and Training

Part 4: Diet, Sex, and Zone 2 Training

Part 5: Longevity and Exercise

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