#858: The Random Show, Couch Edition! — Supplements, Hummingbirds, Cock Rings, Optimizing Mitochondria, Breathing and Balance Training, Cool Grip Strength Tools, and More

Tim Ferriss and Kevin Rose begin "The Random Show" discussing their recent meditation retreat, highlighting its less hardcore approach compared to traditional Zen retreats. They discuss the chef's simple, local approach to food at the Zen center. Tim reveals his ketone ester consumption from Kevin's fridge and cautions against excessive use of 1,3-butanediol, an ingredient in some exogenous ketones, due to potential liver health risks based on animal studies. He likens it to drinking moonshine and mentions Dominic D'Agostino's research in the area. Tim also mentions his eggplant allergy.

Tim and Kevin discuss the benefits of meditation, with Tim describing it as similar to exercise in that different approaches work for different people. He finds Zen retreats helpful for feedback and polishing his practice. Tim experienced blissful calm after a recent retreat. He also shares his theory that meditation stimulates the vagus nerve, activating the inflammatory reflex and reducing systemic inflammation. He connects this to a friend's experience with the 10% Happier app, where meditation alleviated musculoskeletal issues.

Kevin reflects on approaching 50 and the importance of balance, showcasing balance boards and slacklines. He shares a story about Tony Hawk's resilience after a hip injury. Tim shares his experience with a neurologist who diagnosed him with Bertolotti's syndrome, a rare condition involving a transitional vertebra. The doctor's imaging confirmed the source of Tim's pain, which had been dismissed by other specialists.

Kevin gifts Tim a Japanese toothbrush recommended by Craig Mott. Kevin recommends Blue Heritage Japan on Etsy for vintage Japanese items. Tim recommends the 99% Invisible mini-series on "The Power Broker" and the STEM Talk podcast. He highlights Dr. Francisco Gonzalez Lima's research on neurodegenerative diseases, particularly Alzheimer's, and his focus on vascular health and mitochondrial dysfunction.

Tim shares his experience giving ketones to a relative with Alzheimer's, noting improved speech. He discusses Dr. Gonzalez Lima's research on low-dose methylene blue and photobiomodulation. Kevin notes the availability of methylene blue on Amazon, prompting a warning about its potential dangers if overused. Tim mentions the Cognito device, a headset using visual and auditory stimulation for plaque clearance, but expresses concern about compliance. He is interested in photobiomodulation as a more manageable option.

Tim discusses 4x4 Norwegian high-intensity training and its long-lasting cognitive benefits. He explores weight training as an alternative for generating lactic acid while traveling. He also discusses blood flow restriction cuffs for low-weight training, sharing his humbling experience with push-ups using the cuffs. Kevin jokingly suggests using blood flow restriction on the penis.