Latent Space: The AI Engineer Podcast

Shopify’s AI Phase Transition: 2026 Usage Explosion, Unlimited Opus-4.6 Token Budget, Tangle, Tangent, SimGym — with Mikhail Parakhin, Shopify CTO

🔬 Training Transformers to solve 95% failure rate of Cancer Trials — Ron Alfa & Daniel Bear, Noetik

Cancer drug development frequently fails because clinical trials lack precise patient selection, relying on outdated cell line models that fail to translate to human biology. Noetik addresses this by building foundation models trained on proprietary, high-quality multimodal data, including H&E staining, spatial transcr...

Notion’s Token Town: 5 Rebuilds, 100+ Tools, MCP vs CLIs and the Software Factory Future — Simon Last & Sarah Sachs of Notion

Extreme Harness Engineering for Token Billionaires: 1M LOC, 1B toks/day, 0% human code, 0% human review — Ryan Lopopolo, OpenAI Frontier & Symphony

The conversation centers on the emerging discipline of "Harness Engineering," where developers use AI agents to automate the entire software development lifecycle (SDLC). Ryan Lopopolo, from OpenAI’s Frontier team, details his experience building a million-line-of-code Electron application with zero manual code, relyin...

Marc Andreessen introspects on The Death of the Browser, Pi + OpenClaw, and Why "This Time Is Different"

Marc Andreessen, of A16z, joins the Latent Space podcast to discuss the current state and future trajectory of AI. He argues that recent breakthroughs in LLMs, reasoning, agents, and self-improvement mark the culmination of 80 years of AI research, dismissing fears of an "AI winter." Andreessen draws parallels to the d...

Moonlake: Causal World Models should be Multimodal, Interactive, and Efficient — with Chris Manning and Fan-yun Sun

Mistral: Voxtral TTS, Forge, Leanstral, & what's next for Mistral 4 — w/ Pavan Kumar Reddy & Guillaume Lample

🔬Why There Is No "AlphaFold for Materials" — AI for Materials Discovery with Heather Kulik

Dreamer: the Personal Agent OS — David Singleton

Why Anthropic Thinks AI Should Have Its Own Computer — Felix Rieseberg of Claude Cowork & Claude Code Desktop

Retrieval After RAG: Hybrid Search, Agents, and Database Design — Simon Hørup Eskildsen of Turbopuffer

NVIDIA's AI Engineers: Agent Inference at Planetary Scale and "Speed of Light" — Nader Khalil (Brev), Kyle Kranen (Dynamo)

The Latent Space podcast features Nader Khalil and Kyle Kranen from NVIDIA, discussing developer experience, GPU technology, and the company's internal culture. They recount Brev's acquisition by NVIDIA, emphasizing the shared goal of simplifying developer access to GPUs, and touch on NVIDIA's developer experience init...

Cursor's Third Era: Cloud Agents

Every Agent Needs a Box — Aaron Levie, Box

METR’s Joel Becker on exponential Time Horizon Evals, Threat Models, and the Limits of AI Productivity

[LIVE] Anthropic Distillation & How Models Cheat (SWE-Bench Dead) | Nathan Lambert & Sebastian Raschka

🔬Searching the Space of All Possible Materials — Prof. Max Welling, CuspAI

Claude Code for Finance + The Global Memory Shortage: Doug O'Laughlin, SemiAnalysis

⚡️The End of SWE-Bench Verified — Mia Glaese & Olivia Watkins, OpenAI Frontier Evals & Human Data

Bitter Lessons in Venture vs Growth: Anthropic vs OpenAI, Noam Shazeer, World Labs, Thinking Machines, Cursor, ASIC Economics — Martin Casado & Sarah Wang of a16z