The Peter Attia Drive

#227 - AMA #40: Body composition, protein, time-restricted feeding, fasting, DEXA scans, and more

#226 ‒ The science of happiness | Arthur Brooks, Ph.D.

Happiness requires balancing three macronutrients: enjoyment, satisfaction, and purpose. While fluid intelligence—the capacity for innovation—peaks in the late thirties, crystallized intelligence—the ability to synthesize information and teach—grows throughout later life, offering a path to sustained contribution. Many...

#225 ‒ The comfort crisis, doing hard things, rucking, and more | Michael Easter, MA

#224 ‒ Dietary protein: amount needed, ideal timing, quality, and more | Don Layman, Ph.D.

This interview podcast features Peter Attia interviewing Don Layman, a professor emeritus of food science and human nutrition, about muscle-centric nutrition. The discussion begins with Layman's background and then delves into the concept of muscle-centric nutrition, focusing on protein requirements for maintaining an...

#223 - AMA #39: The Centenarian Decathlon, zone 2, VO2 max, and more

The Centenarian Decathlon serves as a strategic mental model for physical training, emphasizing the need to back-cast from desired physical capabilities in the final decade of life. Achieving long-term robustness requires moving beyond generic exercise toward specific, objective-driven training that addresses the inevi...

#222 ‒ How nutrition impacts longevity | Matt Kaeberlein, Ph.D

Nutrition science remains notoriously complex, with few definitive answers regarding its impact on human longevity. Guest Matt Kaeberlein, a leader in the biology of aging, notes that while caloric restriction consistently extends lifespan in laboratory animals, translating these findings to humans is hindered by envir...

#221 ‒ Understanding sleep and how to improve it

Sleep serves as a foundational biological necessity, acting as a vital life-support system that evolution preserved despite its apparent vulnerability. Optimal health requires seven to nine hours of actual sleep, not just time in bed, as sleep efficiency typically hovers around 90%. Brain architecture cycles through no...

#220 ‒ Ketamine: Benefits, risks, and promising therapeutic potential | Celia Morgan, Ph.D.

#219 ‒ Dialectical behavior therapy (DBT): skills for overcoming depression , emotional dysregulation, and more | Shireen Rizvi, Ph.D., ABPP

#218 - AMA #38: Can you exercise too much?

Exercise serves as the most potent tool for longevity, significantly reducing mortality risk across chronic conditions including cardiovascular disease, cancer, and type 2 diabetes. The optimal dose of exercise remains a subject of debate, particularly concerning the "J-curve" hypothesis, which suggests that while mode...

#217 ‒ Exercise, VO2 max, and longevity | Mike Joyner, M.D.

This podcast episode delves into the science of longevity and exercise physiology with physician researcher Mike Joyner. The conversation emphasizes the benefits of exercise for living longer and its importance as we age. The impact of exercise on cardiovascular health, autonomic nervous system, and skeletal muscle blo...

#216 - Metabolomics, NAD+, and cancer metabolism | Josh Rabinowitz, M.D., Ph.D.

#215 - The gut-brain connection | Michael Gershon, M.D.

#214 - AMA #37: Bone health—everything you need to know

Bone health functions as a dynamic, living system rather than an inert structure, playing a critical role in calcium homeostasis and immune function. Bone tissue consists of compact cortical shafts and spongy trabecular ends, both of which undergo constant remodeling through the opposing actions of bone-building osteob...

#213 ‒ Liquid biopsies and cancer detection | Max Diehn, M.D. Ph.D.

Liquid biopsies represent a transformative shift in cancer diagnostics, moving beyond traditional imaging to detect minimal residual disease through circulating tumor DNA (ctDNA). Unlike protein-based biomarkers, which often suffer from poor specificity, ctDNA analysis tracks specific cancer-associated mutations, provi...

Earning the gift of life | Ric Elias (#79 rebroadcast)

#212 - The neuroscience of obesity | Stephan Guyenet, Ph.D.

#211 - AMA #36: Fruits & vegetables—everything you need to know

Fruits and vegetables occupy a central role in dietary discourse, yet scientific consensus remains elusive due to the limitations of long-term, large-scale clinical data. Nutritional strategies must be customized based on an individual's metabolic health, as the requirements for someone with type 2 diabetes or non-alco...

#210 - Lp(a) and its impact on heart disease | Benoît Arsenault, Ph.D.

#209 ‒ Medical mistakes, patient safety, and the RaDonda Vaught case | Marty Makary, M.D., M.P.H.