In this episode of the Ecommerce Lab podcast, host Sebastian Eduard, co-founder and CEO of the leading Amazon PPC agency Insiders, dives into the intricacies of optimizing Amazon PPC campaigns with a focus on effective negation strategies. He advocates for a manual, hands-on approach, highlighting the concept of "global negation" to ensure all relevant campaigns are aligned. Sebastian emphasizes the importance of prioritizing keyword relevance right from the first click and using historical data from Brand Analytics. This data allows sellers to adjust their bids and budgets ahead of Q4, ensuring they maximize profits and focus on net profit instead of misleading metrics like ACOS. Ultimately, he believes the path to success lies in consistent effort, a solid understanding of analytics, and strategic, proactive PPC management.