This episode of *How I Built This* is an interview podcast featuring Sam and Mariah Calagione, founders of Dogfish Head Craft Brewery. The podcast traces their journey from a homebrewed cherry ale in a New York City apartment to the sale of Dogfish Head to Boston Beer Company for approximately $300 million. The Calagiones discuss their unconventional brewing methods, early struggles with funding and regulations, and the importance of building a strong brand identity through unique beers and community engagement. A key takeaway is their emphasis on culinary inspiration in brewing, defying traditional purity laws to create distinctive beers. The interview highlights the couple's complementary business skills and enduring partnership, both personally and professionally, contributing to their remarkable success.