This podcast episode focuses on common mistakes in Amazon PPC keyword negation strategies, particularly over-negation. The hosts discuss three frequent errors: negating keywords with high ACOS, negating keywords with high spend and no sales, and negating keywords with no sales regardless of click volume. They emphasize that often, the issue isn't the keyword itself but rather the bid amount, advocating for adjusting bids instead of automatically negating. The hosts recommend negating only irrelevant keywords with sufficient volume, using conversion rate and clicks-to-conversion as key metrics to identify problematic keywords, and avoiding automated negation systems.