This episode explores the application of Motivational Interviewing (MI) in the medical field, specifically within the context of primary care. Dr. Damara Gutnick, a physician with extensive experience at Bellevue Hospital, recounts her journey of initially dismissing MI's relevance to her practice, only to later embrace it as a crucial tool for improving patient engagement and overcoming challenges like non-adherence to treatment plans. Against the backdrop of increasing physician burnout and time constraints in primary care, Dr. Gutnick highlights how MI, even when applied in short bursts ("sprinkling"), significantly enhances patient-physician rapport and improves treatment outcomes. For instance, she shares a case where a simple affirmation transformed a hostile patient interaction into a collaborative one. More significantly, the discussion pivots to the "What Matters To You" approach, emphasizing the importance of understanding patients' social determinants of health to address the root causes of non-compliance. This approach, deeply rooted in MI's principles, allows physicians to connect with patients on a deeper level, even if they cannot directly solve all their problems. Ultimately, this episode underscores the transformative potential of MI in enhancing both patient care and physician well-being, suggesting a shift from a purely biomedical approach to a more holistic and patient-centered model.