This podcast episode explores various aspects of Alzheimer's disease and dementia, including their causes, symptoms, diagnosis, and potential treatment options. The conversation highlights the rising concern and impact of dementia on society, emphasizing the need for non-invasive testing and personalized treatment decisions. It discusses the role of genetic factors, such as APOE genotype, in assessing the risk of side effects from treatments and the potential use of intranasal insulin and body composition in preventing Alzheimer's. The association between Alzheimer's disease and risk factors like obesity and hearing impairment is also examined, along with the importance of deep sleep and lifestyle factors in maintaining brain health. The concept of cognitive reserve and its relationship with cognitive decline is explored, and the potential benefits and limitations of hormone replacement, neuroprotective compounds, and medications are discussed. The episode concludes by addressing the impact of medications and infections on cognitive health and highlighting ongoing research on chronic inflammation and the gut biome in relation to brain diseases.
